The relationship between visceral fat depots and markers of renal dysfunction in patients with borderline arterial hypertension and obesity

Abstract Introduction Obesity is a potent risk factor for the development of kidney disease (CKD). The localization adipose tissue and its hormonal activity plays an important role in formation cardiorenal relationship. Purpose work To assess relationship between visceral fat stores with tissue, metabolic parameters markers renal dysfunction patients borderline arterial hypertension (AH) obesity. Materials methods study included 100 people aged 44.8±6.4 years. Group 1 – SBP 134.1±4.7 mm Hg; DBP 84.3±5.9 Hg, BMI 36.1±3.2kg/m2. 2 was 35.5±3.9 kg/m2, level 120.6±10.1 Hg 70.1±8.4 Hg. Albumin/creatinine ratio urine (ACRU), β2 microglobulin, tumor necrosis (TNF), interleukin 6 (IL6), monocytechemoattractant protein (MCP-1) determined single portion morning urine, leptin, resistin cystatin C by ELISA. Glomerular filtration rate (GFR) calculated using CKD-EPI formula (Hoek's formula). examination (VAT) ultrasound method investigation: epi- pericardial depots were assessed; VAT measurement at navel from inner surface rectus abdominis to posterior wall aorta L4; thickness perirenal on right left area both sides. Result amount groups shown Table 1. Indicators are presented 2. In group ALT levels (r=0.40) (r=0.42) established, AST (r=0.52) (r=0.47); HDL (r=−0.67) (r=−0.70), TG (r=0.38) (r=0, 39), HOMA index (r=0.45) (r=0.39), MCP-1 (r=0.28) (r=0.36). Perineal depot located correlated LDL (r=0.37), glucose (r=0.49) (r=0.50), ACRU (r=0.43) (r=0.57), urinary excretion 39). connection optimal blood pressure control established perineal (r=0.35) (r=0.29), GFR according Hoek (r=0.29) 38), (r=0.36) (r=0.29). Findings increase perinephral obese associated cytokine accompanied deterioration parameters. FUNDunding Acknowledgement Type funding sources: None.